Background: Pregnancy may be the only time that a woman presents for medical care and when an opioid use disorder can be identified and treated. Objectives: The aim of this study, determination of Maternal and Neonatal Outcomes in mothers using opioids. Methods: This prospective cohort study was carried out on 159 pregnant women who used opioids and 474 healthy subjects in Kamali Hospital in Karaj from 2014 to 2017. The data were collected using a checklist, containing social, midwifery, obstetric, and Neonatal data. Data were analyzed by SPSS 19. Results: In the present study, there were no significant differences between the two exposed and non-exposed groups in terms of mean age, pregnancy/Maternal characteristics; however, there were significant differences in terms of weight gain and care services (P < 0. 001). The frequency of all kinds of drugs; Methamphetamine with 27. 7%; heroin with 25. 8%; and opium with 24. 5% were the most consumed drugs. Among the newborns in the two groups, the first and fifth minutes of Apgar score, weight, and admission were significant (P < 0. 001). The prevalence of infants less than 2500 in the group faces 21. 4% in contrast to 3. 4% in the non-exposed group. Conclusions: Given the increasing number of mothers consuming Opioids within pregnancy and the irreparable side effects of these drugs, it is important to pay attention to this and to provide coping strategies.

To describe antenatal Maternal complications and Neonatal Outcomes caused by gestational diabetes mellitus. Materials and Methods: This descriptive observational study was conducted in the Department of Obstetrics and Gynaecology (Obs & Gynae), Bahawal Victoria Hospital, Bahawalpur, Pakistan, over a the period of one year, from January 1 to December 31, 2003. Fifty pregnant women diagnosed by glucose tolerance tests as diabetics were enrolled as study subjects and followed regularly at the Obs & Gynae out-patient department. Blood glucose levels were controlled by diet per se or with insulin and subjects were hospitalized for insulin dose adjustment and management of complications. Feotal well being was assessed by ultrasound, kick count and cardiotocography. Time and mode of delivery was decided upon at 36th week of gestation.Intra-partum Maternal blood glucose level was monitored and fetal monitoring was done by external cardiotocography.Results: Out of a total of 1429 women delivered, 50(3.5%) were diagnosed as GDM and studied. Forty-four (88%) patients were above 25 years of age and 38(76%) were multiparous. Thirty-two (64%) subjects required insulin to control GDM. Most frequent Maternal and feotal complications were polyhydramnios 9(18%) and macrosomia 18(36%), respectively. One out of fifty subjects had a spontaneous miscarriage and one had intrauterine death. Caesarean section was done in 29(58%) patients. Total number of babies delivered alive were 48(96%).Conclusion: GDM was diagnosed in 3.5% of pregnant women. Most of the subjects were above 25 years and multiparous. Most common Maternal complication was polyhydramnios and caesarean section was a common mode of delivery. Macrosomia and jaundice were most prominent complications among neonates.

Background & Objective: Although the safety of cesarean sections has increased, there are still considerations, especially for women with a history of repeated cesarean sections. This study was conducted with the aim of investigating Maternal and Neonatal Outcomes in candidates for cesarean sections due to repeat cesarean sections according to the number of previous cesarean sections.Materials & Methods: This prospective descriptive study was conducted from April 2020 to June 2022 at Taleghani Hospital. All candidates for cesarean sections due to repeated cesarean sections were included in the study. According to the number of previous cesarean sections, they were divided into three groups. Statistical analysis was performed with Kruskal-Wallis, Chi-squared and Fisher’s exact tests. A P value < 0.05 indicated statistical significance.Results: A total of 345 women were included in the study. The results of this study showed that these three groups were significantly different in terms of duration of surgery (P<0.001), abnormal placental adhesion (0.012), and the presence of intraperitoneal adhesions (P<0.001), but there was not a significant difference in terms of other Maternal and Neonatal Outcomes (P<0.05).Conclusion: The results of this study showed that an increase in the number of previous cesarean sections does not increase most Maternal and Neonatal complications during a current cesarean section. Of course, it should be noted that the number of women with a history of three or more previous cesarean sections was small in this study, and for this reason, more studies are needed.

Background: The coronavirus (COVID-19) pandemic has caused global uncertainty. Recent studies indicate an increased risk of spontaneous abortion, spontaneous preterm labor, and severe Maternal and Neonatal complications caused by COVID-19. Objectives: The aim of our study is to investigate the impact of COVID-19 infection on Maternal and Neonatal perinatal Outcomes. Methods: This is a non-interventional, analytical clinical study. We conducted a retrospective analysis of 410 histories of pregnant women admitted to hospitals from 2020 to 2022 in the City Infectious Disease Centre and the City Infectious Disease Hospital of Shymkent. Results: In the main group, there were 48 (21.0%) babies, while in the control group, there were 18 (10.5%) babies. A weight above 2500 g was recorded in 79% (182) of newborns in the main group. When comparing the weight of newborns between the groups, we did not find statistically significant differences (P = 0.051). Births of babies weighing more than 2500 g were 2.26 times more common in the control group than in the main group (95% CI: 0.984 - 5.228). A birth height of less than 48 cm was recorded in 1.7% (3) cases in the control group and 13.8% (32) of newborns in the main group (P = 0.002). A birth height greater than 48 cm was recorded in 86.2% (198) of neonates in the main group and 98.3% (84) in the control group. Conclusions: A large systematic review (28 studies involving 790,954 pregnant women, among whom 15,524 were diagnosed with SARS-CoV-2 infection) aimed to investigate the relationship between SARS-CoV-2 infection during pregnancy and the risk of pre-eclampsia. It should also be noted that SARS-CoV-2 during pregnancy increases the likelihood of developing severe pre-eclampsia and HELLP syndrome. In our study, preeclampsia (54 - 13.1%) and HELLP syndrome (4 - 1.1%) were more frequent in the main group than in the comparison group. It should also be noted that frequent complications of COVID-19 in pregnant women included preterm labor (80 - 19.4%) and antenatal fetal death (8 - 2.0%).Analysis of perinatal Outcomes revealed that women with COVID-19 infection are significantly more likely to give birth to infants with low growth, prematurity, and lower Apgar scores, and these infants are more likely to stay in the Neonatal pathology department compared to those born to women without COVID-19 infection.